Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune responsiveness after organ or cell transplantation. In many settings, immunoregulatory activity is enriched in CD4+ T cells that express high levels of CD25, and common mechanisms appear to be responsible for the activity of regulatory T cells in both transplantation and the control of reactivity to self-antigens.

Original publication

DOI

10.1097/01.TP.0000106477.70852.29

Type

Journal article

Journal

Transplantation

Publication Date

15/01/2004

Volume

77

Pages

S6 - S8

Keywords

Cytokines, Humans, Isoantigens, Organ Transplantation, T-Lymphocytes, T-Lymphocytes, Regulatory, Transplantation Tolerance